李卓玉教授，女，博士生导师，山西大学生命科学学院院长，化学生物学教育部与分子工程重点实验室主任，山西大学生物技术研究所所长，享受政府特殊津贴专家。李卓玉于2001年博士毕业于德国Kaiserslautern大学生物化学系，随后进入英国Dundee大学生物医学中心从事大肠癌发生发展分子机制的研究工作。2009年8月全职回到山西大学工作。近年来主要从事大肠癌分子靶点的发现及天然产物功能分子干预机制的研究。研究成果已在Oncogene，BBA-Reviews on Cancer，Journal of Agriculture and Food Chemistry，Food Function，Journal of Functional Foods等国内外高端杂志公开发表论文116篇，其中SCI论文90篇；获批国家发明专利多项，处在临床前开发阶段的天然药物2个，在国际基因库发表抗癌新基因1个；带头申请获批“1331工程”山西特色生物资源与健康产业协同创新中心；同时带领自己的团队申报获批“1331工程”重点创新团队—山西特色谷物资源抗肿瘤功能分子研发创新团队。于2018年获得全国三八红旗手荣誉称号；2017年获得山西省科学技术奖（自然科学类）一等奖；2016年中国产学研合作个人创新奖；2017、2018年全国大学生生命科学创新创业大赛指导教师一等奖。
负责项目
1．国家自然科学基金面上项目，李卓玉，谷糠结合态多酚通过miRNA-149逆转结肠癌多药耐药的活性成分及分子机制（31770382），2018.01-2021.12，60万元，在研；
2．国家自然科学基金面上项目，李卓玉，Beta-连环素与GRP78相互作用调控大肠癌细胞能量代谢的分子机制研究（31271516），2013.01-2016.12，85万元，已结题；
3．山西省回国留学人员重点科研资助项目，李卓玉，小米米糠过氧化物酶诱导结肠癌细胞凋亡的分子机制（2015-重点2），2015.12-2018.12，30万元，在研；
4．国家自然科学基金专项基金项目，李卓玉，结肠腺瘤息肉蛋白突变引发Gardner综合症及其纤毛生长紊乱之分子机制研究（81150026），2012.01-2012.12，15万，已结题；
5．山西省科技基础条件平台建设项目，李卓玉，靶向抗肿瘤重组多肽类药物平台建设（2015091015），2015.01-2016.12，15万元，已结题；
6．山西省应用基础研究计划重点项目，李卓玉，PKM2介导的自噬调控肿瘤耐药的分子机制及抗肿瘤耐药的药物筛选（201801D111001），2018.12-2020.12, 30万元，在研；
7．国家自然科学基金青年基金项目，李宗伟，乙酰化修饰在大肠癌细胞GRP78蛋白分泌中的调控作用（31201072），2013.01-2015.12，24万元，已结题；
8．国家自然科学基金青年基金项目，单树花，谷糠过氧化物酶FMBP抗结肠癌的细胞膜靶点及效应结构域研究（31500630），2016.01-2018.12，20万元，在研；
9．国家自然科学基金青年基金项目，丁国斌，具靶向识别与肿瘤酸性微环境特异穿膜功能的新型药物-siRNA共传输体系的构建与评价（31500771），2016.01-2018.12，21万元，在研；
10．国家自然科学基金青年基金项目，晋小婷，环境PM2.5通过PPARa介导的心肌能量代谢重构诱导心力衰竭的毒性机制（21707085），2018.01-2020.12，24万元，在研；
11．国家自然科学基金青年基金项目，杨鹏，分泌型PKM2调控肿瘤相关巨噬细胞极化促进结肠癌化疗抵抗的机制研究（31800657），2019.01-2021.12，25万元，在研；
12．国家自然科学基金青年基金项目，武海丽，沙棘叶结合态多酚通过调控PKM选择性剪接抑制Warburg效应的抗肿瘤活性成分及作用机制（31800290），2019.01-2021.12，25万元，在研；
13．国家自然科学基金青年基金项目，张立超，丹酚酸A通过抑制GRP78分泌调控微环境逆转肿瘤耐药的分子机制（81803791），2019.01-2021.12，20万元，在研；
14．国家自然科学基金青年基金项目，史江颖，芹菜素与PKM2相互作用抑制有氧糖酵解发挥抗肿瘤效应的分子机制（81803238），2019.01-2021.12，21万，在研；
15．山西省应用基础研究项目，晋小婷，TBBPA通过影响巨噬细胞极化介导子宫内膜癌恶化的分子毒理研究（201701D221244），2017.07-2019.12，3万元，在研；
16．山西省应用基础研究项目（优秀青年基金项目），李宗伟，葡萄糖调节蛋白78调控肿瘤细胞自噬的分子机制（201601D021007），2016.07-2018.12，10万元，在研；
17．山西省基础研究项目，单树花，小米米糠蛋白通过活性氧靶向诱导结肠癌细胞凋亡的分子机制（2015021200），2015.01-2017.12，3万元，在研；
18．山西省基础研究项目，丁国斌，基于高分子材料多靶向磁性纳米给药系统的构建及其抗肿瘤效应研究（2013021014-1），2013.01-2015.12，5万元，已结题；
19．山西省应用基础研究项目，杨鹏，M2型丙酮酸激酶调控结肠癌细胞自噬的分子机制（201601D021107），2016.07-2018.12，4万元，在研；
20．山西省高等学校科技创新项目，单树花，小米米糠蛋白抗结肠癌效应的分子机制，2015.03-2017.03，2万元，在研；
21．山西省高等学校科技创新项目，丁国斌，以GRP78为靶点、顺序靶向细胞膜和细胞核的智能阿霉素原药的合成及抗肿瘤效应研究（2015116），2015.03-2017.03，3万元，在研；
22．山西省应用基础研究计划青年面上项目，张立超，肿瘤分泌型GRP78通过调节脂代谢促进巨噬细胞M2型极化的机制研究
2011-2014：负责主持高等学校博导基金一项（12万），项目编号：20111401110011
2010-2011：负责主持国家基金一项（10万），项目编号：31040018
2010-2013：负责支持山西省海外百人项目一项（100万），已结题
2010-2012：负责主持山西省留学基金一项（10万）；省人才引进专项（30万）
2003-2005：负责主持国家基金一项(20万，已结题)，项目编号：30270292
1997-2003：负责主持多个山西省青年基金；山西省自然科学基金；山西省留学基金
社会工作
2018年9月9日：山西省药学会第六届理事会常务理事
2015年1月：《中国细胞生物学学报》第七届编委
2014年5月：山西省第七届微生物学会理事长
2014年7月：山西省欧美同学会第二届常务理事
获得荣誉
2018年：全国三八红旗手
2018年：享受政府特殊津贴专家
2018年，山西省新兴产业领军人才
2018年：第五届科教兴晋突出贡献专家
2018年：山西省研究生教育优秀导师
2018年：第三届全国大学生生命科学创新创业大赛指导教师一等奖
2017年：第二届全国大学生生命科学创新创业大赛指导教师一等奖
2017年：山西省科学技术成果奖（自然科学类）一等奖
2017年：山西省五一劳动奖章
2016年：山西省科学技术成果奖（自然科学类）一等奖
2016年：中国产学研合作个人创新奖
2014年：全国优秀科技工作者
2014年：第六届“山西省十佳中青年优秀科技工作者”
2013年：第七届山西省优秀科技工作者
2013年：浙江省“钱江学者”
2013年：山西省“131”领军人才
2013年：“三育人”先进个人
2012年：山西省学术技术带头人
2010年：山西省“百人计划”海外引进人才
2010年：山西省科技奉献奖“先进个人二等奖”（山西省科协）
2010年：山西省高等学校科学技术成果奖自然科学类一等奖（山西省教育厅）
2010年：山西省自然科学三等奖 （山西省科技厅）
近年发表论文:
Rong Fu, Peng Yang, Amin Sajid, Zhuoyu Li*. Avenanthramide A induces cellular senescence via miR-129-3p/Pirh2/p53 signaling pathway to suppress colon cancer growth. Journal of Agricultural and Food Chemistry, 2019. DOI: 10.1021/acs.jafc.9b00833. IF 3.412
Xiaoting Jin, Huilan Su, Guobin Ding, Zhendong Sun, Zhuoyu Li*. Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissues. Chemosphere. 2019, 224:29-38. IF 4.426
Xiaoting Jin, Bin Xue, Rifat Zubair Ahmed, Guobin Ding, Zhuoyu Li*. Fine particles cause the abnormality of cardiac ATP levels via PPARɑ-mediated utilization of fatty acid and glucose using in vivo and in vitro models. Environmental Pollution. 2019, 249:286-294. IF 4.43
Xiaoqin La, Lichao Zhang, Zhuoyu Li*, Hanqing Li, Yufei Yang. (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway, Journal of Agricultural and Food Chemistry. 2019,67(9):2510–2518. IF 3.412
Xiaoqin La, Lichao Zhang, Yufei Yang, Hanqing Li, Guisheng Song, Zhuoyu Li*. Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling, Cellular Signalling. 2019,60:1-16. IF 3.487
Jiangying Shi, Shuhua Shan, Guofang Zhou, Hanqing Li, Guisheng Song, Zhuoyu Li*, Dongfeng Yang. Bound polyphenol from foxtail millet bran exhibits an antiproliferative activity in HT-29 cells by reprogramming miR-149-mediated aerobic glycolysis. Journal of Functional Foods. 2019,56:246-254. IF 3.47
Xiaoli Zhang, Shuhua Shan, Hanqing Li, Jiangying Shi, Yang Lu and Zhuoyu Li*. Cloning, expression of the truncation of recombinant peroxidase derived from millet bran and its reversal effects on 5-Fu resistance in colorectal cancer. International Journal of Biological Macromolecules. 2019, 19:132:871-879. IF 3.909
Shuhua Shan, Yue Xie, Huiling Zhao, Jinping Niu, Sheng Zhang, Xiaoli Zhang and Zhuoyu Li*. Bound polyphenol extracted from jujube pulp triggers mitochondria-mediated apoptosis and cell cycle arrest of HepG2 cell in vitro and in vivo. Journal of Functional Foods, 2019, 53:187-196. IF 3.470
Bin Jia, Shi T, Li Z, Shan-Hua Shan, Ji P, and Zhuoyu Li*. Toxicological effects of bisphenol A exposure-induced cancer cells migration via activating directly integrin β1. Chemosphere. 2019, 220:783-792. IF 4.427
Guobin Ding, Gengfeng Wu，Binchun Li, Peng Yang and Zhuoyu Li*. High-yield expression in Escherichia coli, biophysical characterization, and biological evaluation of plant toxin gelonin. 3 Biotech. 2019,9:19-26. IF 1.497
Shuhua Shan, Yue Xie, Huiling Zhao, Jinping Niu, Sheng Zhang, Xiaoli Zhang, Zhuoyu Li*. Bound polyphenol extracted from jujube pulp triggers mitochondria-mediated apoptosis and cell cycle arrest of HepG2 cell in vitro and in vivo. Journal of Functional Foods. 2019,53:187-196.IF 3.52
Yufei Yang, Lichao Zhang, Xiaoqin La, et al. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion, Naunyn-Schmiedeberg's Archives of Pharmacology, 2018,392(4):467-480. IF:2.238
Peng Yang, Guo-Bin Ding, Wen Liu, Rong Fu, Amin Sajida and Zhuoyu Li*. Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation. Food & Function. 2018, 9: 5547-5559. IF 2.791
Yang Lu, Shuhua Shan, Hanqing Li, Jiangying Shi, Xiaoli Zhang, and Zhuoyu Li*. Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell. Journal of Agricultural and Food Chemistry. 2018, 66, 5190-5199. IF 3.412
Guo-Bin Ding#*, Junqing Sun#, Gengfeng Wu, Binchun Li, Peng Yang, Zhuoyu Li*, Guangjun Nie*. Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional Beclin 1. ACS Applied Materials & Interfaces, 2018, 10 (6), 5227–5239. IF 8.097
Guobin Ding, Junqing Sun, Peng Yang, Binchun Li, Ying Gao, and Zhuoyu Li*. A Novel Doxorubicin Prodrug with GRP78 Recognition and Nucleus-Targeting Ability for Safe and Effective Cancer Therapy. Molecular pharmaceutics, 2018, 15 (1): 238-46. IF: 4.44
Songjia Guo, Xinxin Liang, Min Guo, Xiaoli Zhang, Zhuoyu Li*. Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.International Journal of Biological Macromolecules.2018,119: 669-676. IF 3.57
Li Song*, Xiaobo Xua, Zhuoyu Li. A serine protease extracted from Trichosanthes kirilowii inhibits epithelialmesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human colorectal adenocarcinoma cells. Journal of Functional Foods, 40 (2018) 639–647. IF 3.57
Xiaoting Jin, Bin Xue, Qunfang Zhou, Ruijun Su, Zhuoyu Li*. Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure. The Journal of Toxicological Science. 2018, 43 (2):101-111. IF: 1.719
Xiaoting Jin, Ruijun Su, Ruijin Li, Long Cheng and Zhuoyu Li*. Crucial role of pro-in？ammatory cytokines from respiratory tract upon PM2.5 exposure in causing the BMSCs differentiation in cells and animals. Oncotarget, 2018, 9 (2):1745-1759.
Xiaoqin La, Lichao Zhang, Hanqing Li, Zhuoyu Li*, Guisheng Song, Peng Yang and Yufei Yang, et al. Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways. Oncotarget, 2018, 9 (21): 15464-79.
Wu, H., T. Zhang, F. Pan, C. J. Steer, Zhuoyu Li, X. Chen and Guisheng Song. MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis. Journal of Hepatology. 2017, 66(4): 816-824. IF: 12.486
Wu, H., J. Tao, X. Li, T. Zhang, L. Zhao, Y. Wang, L. Zhang, J. Xiong, Z. Zeng, N. Zhan, C. J. Steer, L. Che, M. Dong, X. Wang, J. Niu, Zhuoyu Li, G. Yan, X. Chen and Guisheng Song. MicroRNA-206 Prevents the Pathogenesis of Hepatocellular Carcinoma Via Modulating Expression of cMet and Cdk6. Hepatology. 2017, 66(6): 1952-1967. IF: 13.246
Guobin Ding, Junqing Sun, Zhuoyu Li*. An intelligent doxorubicin prodrug with GRP78 recognition and sequential targeting ability to tumor cell membrane and nucleus. Journal of Controlled Release, 2017, 259, e39. IF: 7.786
Shuhua Shan, Jiangying Shi, Peng Yang, Bin Jia, Haili Wu, XiaoLi Zhang, Zhuoyu Li*. Apigenin restrains colon cancer cell proliferation via targetedly blocking the PKM2-dependent glycolysis. Journal of Agricultural and Food Chemistry. 2017, 65, 8136？8144. IF 3.154
Jiangying Shi, Shuhua Shan, Hanqing Li, Guisheng Song, Zhuoyu Li*. Anti-inflammatoryeffectsofmilletbranderived-bound polyphenols in LPS-induced HT-29 cell via ROS / miR-149 / Akt / NF-κB signaling pathway. Oncotarget. 2017. 8 (43): 74582-74594. IF 5.168
Xiaoqin La, Lichao Zhang, Zhuoyu Li, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017, 8 (13): 20909-20924. IF: 5.168
Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li*. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular Signalling. 2017, (37): 136-148. IF 4.4
Ruijun Su, Xiaoting Jin, Weifang Zhang, Zhuoyu Li*, Xiaona Liu, Jie Ren. Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway. Chemosphere. 2017, 167, 444-453. IF 3.69
Li Song, Linlin Guo, Zhuoyu Li*. Molecular mechanisms of 3,3′4,4′,5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2017, 322, 75-88. IF 3.847
Yingying Wang#, Haili Wu#, Peng Yang, Zongwei Li, Zhuoyu Li*. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Experimental Cell Research. 2017, 351 (1): 24-35. IF 3.378
Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific Reports. 2016; 6: 30406-30417.IF 5.228
Haili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu,Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li*. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget. 2016, 7 (47): 78069-78082. IF 5.168
Haili Wu, Yingying Wang, Changxin Wu, Peng Yang, Hanqing Li, Zhuoyu Li*. Resveratrol induced cancer cell apoptosis through miR-326/PKM2 mediated ER stress and mitochondrial fission. Journal of Agricultural and Food Chemistry. 2016, 64 (49): 9356-9367. IF: 3.154
Haili Wu, Yingying Wang, Peng Yang, Zongrui Li, Hanqing Li, Changxin Wu, Zhuoyu Li*. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. American Journal of Cancer Research. 2016, 6 (10): 2221-2234. IF: 3.425
Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC Biotechnology. 2016, 16(1): 1-13. IF: 2.45
Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere. 2016,144,459-466. IF 3.69
Xiaoting Jin, Meilan Chen, Ruijin Li, Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng, Zhuoyu Li*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90(8), 1929-1938. IF 6.68
Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao M, Weiping Liu. Dichlorodiphenyldichloroethylene Dichlorodi exposure reduces r-GCSvia suppressed Nrf2 in HepG2 cells. Environmental Toxicology. 2016, 31(3): 350-359. IF2.7
Min Guo, GuoBin Ding, Peng Yang, Lichao Zhang, Haili Wu, Hanqing Li, Zhuoyu Li*. Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. Journal of Agricultural and Food Chemistry.2016, 64, 6277-6285. IF 3.154
Li Song, Jiao Chang and Zhuoyu Li*.A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKTmediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & Function. 2016, 7(2): 843-54.IF 2.791
Tonglin Shi, Cao Zhao, Zhuoyu Li*, Quanbin Zhang, Xiaoting Jin. Bisphenol A exposure promote the migration of NCM460 cells via estrogen receptor-mediated integrin β1/MMP-9 pathway. Environmental Toxicology. 2016, 31(7): 799-807. IF 2.7
Peng Yang, Zhuoyu Li, Hanqing Li*, Potential roles of proteases inhibitors in cancer progression. Asian Pacific journal of cancer prevention. 2015, 16 (18), 8047-8052. IF 2.514
Jiangying Shi, Shuhua Shan, Zongwei Li, Hanqing Li, Xinfeng Li, Zhuoyu Li*. Bound polyphenol from foxtail millet bran induces apoptosis in HCT-116 cell through ROS generation.Journal of Functional Foods. 2015,17: 958-968. IF 3.57
Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.Cellular Signalling. 2015, 27: 1525-1532. IF 4.4
Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications, 2015, 459(2), 327-332. IF 2.4
Shuhua Shan, Jiangying Shi, Zhen Li, Huixiang Gao, Tonglin Shi, Zongwei Li, Zhuoyu Li*. Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. Food & Function. 2015, 6(7): 2331-2338. IF 2.7
Min Guo, Guobin Ding, Songjia Guo, Zhuoyu Li*, Liangqi Zhao, Ke Li, Xiangrong Guo. Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch. Food & Function. 2015, 6, 3035-3044. IF 2.7
Tonglin Shi, Lichao Zhang, Zhuoyu Li*, Ian P Newton Quanbin Zhang. Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of Escherichia coli.Protein Expression and Purification. 2015, 107:13-19. IF 2.8
Zongwei Li, YingyingWang, Ian P. Newton, Lichao Zhang, Pengyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ. Cellular Signalling. 2015, 27: 1237-1245. IF 4.4
Songjia Guo, Shuhua Shan, Xiaoting Jin, Zongwei Li, Zhuoyu Li*, Lichao Zhao, Quan An, Wei Zhang. Water Stress Proteins from Nostoc commune Vauch. Exhibit Anti-Colon cancer activities in Vitro and in Vivo. Journal of Agricultural and Food Chemistry.2015, 63(1): 150-159. IF 3.1
Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li*, Zhuoyu Li*,Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion viaautocrine TGF-β/Smad2/3 signaling. International Journal of Biochemistry & Cell Biology. 2015, 64, 202-211. IF 4.5
Li Song, Meirong Zhao, Jianxin Liu, Zhuoyu Li*, Hong Xiao, Weiping Liu. p, p’- Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways. Toxicology Research. 2015, 4, 1214-1224. IF 3.983
Li Song, Zhuoyu Li*, Wei-Ping Liu, Mei-Rong Zhao. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biology & Therapy. 2015, 16, 1-7. IF 3.072
Tonglin Shi, Zongwei Li, Quanbin Zhang, Dawen Zheng and Zhuoyu Li*. Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model.Pakistan Journal of Pharmaceutical Sciences. 2015, 28: 1997-1999. IF 0.682
Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang, Zhuoyu Li*. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling.Oncotarget. 2014, 30; 5(14): 5369-5380. IF 6.6
Li Song, Jianxin Liu, Zhuoyu Li*, Meirong Zhao, Weiping Liu. P’-dichlorodiphenyl-dichloroethylene induces colorectal Adenocarcinoma Cell Proliferation through Oxidative Stress. PLoS One. 2014, 9(11): e112700. IF 3.7
Shuhua Shan, Zongwei Li, Songjia Guo, Zhuoyu Li*, Tonglin Shi, Jiangying Shi. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer. Journal of Functional Foods. 2014, 10: 444-455. IF 4.4
Li song, Junyu Zhao, Xiaotiing Jin, Zhuoyu Li*, Ian P Newton, Weiping Liu, Hongxiao, Meirong Zhao. The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling.Toxicology Letters. 2014, 229(1): 284-91. IF 3.2
Li Song, Yuxin Jia, Wensi Zhu, Ian P Newton, Zhuoyu Li*, Wenlin Li. N-terminal trunctions of adenomatous polyposis coli are associated with primary cilia defects.International Journal of Biochemistry & Cell Biology. 2014, 21(55): 79-86. IF 3.247
Yanan Peng, Zongwei li, Peng Yang, Ian P Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrowmesenchymal stem cells into tumor associated fibroblasts.Biochemical and Biophysical Research Communications. 2014, 451(1): 68-73. IF 2.281
Haili wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng fan, Zhuoyu Li*, PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway intumor cells. Cellular Signaling. 2014, 26(11): 2397-405. IF 4.4
Zongwei Li, Peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. BBA-Reviews on Cancer. 2014, 1846(2): 285-296. IF 8.8
Xiaoting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. Toxicology, 2014, 322: 99-108. IF 3.8
Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular. Toxicology Letters. 2014, 225:158-166. IF 3.2
Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilites colon cancer migration via the modulation of ATAT3 signaling.Cellular Signaling. 2014, 26(9): 1853-1862. IF 4.4
Shuahua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li*, Maolin Guo. A novel protein extraxted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. Toxicology Letters. 2014, 227: 129-138. IF 3.2
Rong Fu, Yang Peng, Haili Wu, Zongwei, Li, Zhuoyu Li*, GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/AKT signaling. Asian Pacific Journal ofCancer Prevention. 2014, 15 (17): 7245-7249. IF 1.7
Zongwei Li, Lichao Zhang, Hanqing Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Reports. 2014,47(8): 445-450. IF 1.7
Zongwei Li, Chao Zhao, Zhuoyu Li*, Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo Li. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. International Journal of Biochemistry & Cell Biology, 2014, 47: 68-75. IF 4.5
Xiaoting Jin, Li Song, Xiangyuan Liu, Meilian Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p’-DDT-induced cytotoxicity via the ROS –mediated mitochondrial pathway and NF-kB/FasL pathway. PLoS One. 2014, 9(12): e113257. IF 3.7
Yanan Peng, Zongwei Li, Zhuoyu Li*. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts.Biochemical and Biophysical Research Communications, 2013, 440(4): 558-63.IF 2.5
Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, Zhuoyu Li*. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. International Journal of Biochemistry & Cell Biology, 2013, 45(5): 987-994. IF 4.5
Cui Wang, Zhuoyu Li, Quan Zhang, Meirong Zhao, Weipiing Liu. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications ofchairality in risk assessment of POPs metabolisms. Environmental Science&Technology. 2013, 6; 47(8): 3909-3917. IF 5.1
Zhuoyu Li*, Wenling Li, Wensi Li, Li Song, Cilia, adenomatous polyposis coli and associated diseases. Oncogene, 2012, 31(12): 1475-83. IF 8.5
Zongwei Li, Zhuoyu Li*. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. BBA-reviews on Cancer. 2012, 1826(1): 13-22．IF 8.8
Scott A Nelson, Zhuoyu Li, Ian P Newton，David Schiffmann，Cornelis J. Weijer，Paul L. Appleton，Inke S. N？thke，Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Disease Models & Mechanisms，2012, 5(5): 1-7. IF 4.5
Lixi Niu, Chenyun Guo, Jingming Yuan, Zhuoyu Li*, Potential roles of recombinant acetylcholine receptor α subunit 1-211 in immunoadsorbent and DNA immunization.Journal of Immunological Methods, 2011 30; 372(12): 14-21. IF 2.340
Yingqi Li, Zhuoyu Li*, Xueping Zhou, Pin Yang. Detection of Nano Eu2O3 in cells and study of its biological effects. Nano Biomedicineand Engineering, 2010, 2(1):32-45. IF 1.3
Dina Dikovskaya, Zhuoyu Li, Ian P Newton, Iain Davision, Paul Clacke and Inke S Nathke. Microtubule assmbly by the Apc protein is regulated by importin-β-RanGTP,Journal of Cell Science, 2010, 123: 1242-1253. IF 6.290
Zhuoyu Li, Karin Kroboth, Ian P Newton, Inke S Nathke. Novel self-association of NH2-terminal regions of the Adenomatous polyposis coli protein regulates APC cluster formation and cell migration. Journal of Cell Science, 2008, 121: 1916-1925. IF 6.290
Zhuoyu Li*, Yanfeng Qu, Hanqing Li, Jingming Yuan. Truncations of gelonin lead to a reduction in its cytotoxicity. Toxicology，2007, 7; 231(2-3):129-136. IF 3.641
Kroboth, K, Newton, I.P, Zumbrunn, J, Zhuoyu, Li, Kita, K, Waterman-Storer, C.M, N？thke, I.S. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Molecular Biology of the Cell, 2007,18: 910-918. IF 5.861
Martin Hossan; Zhuoyu Li, Yawei Shi, Ulrike Kreilinger, Jorn Butter, Pia D Vogel, Jingming Yuan, John Wise, Wolfgang E. Trommer, Novel immunotoxin: a fusion protein consisting of gelonin and acetylcholine receptor fragment as a potential immunotherapeutic agent for the treatment of Myasthenia gravis. Protein Expression and Purification, 2006, 46: 73-84. IF 1.644
Zhuoyu Li, Inke S N？thke. Tumor-associated NH2-terminal fragments are the most stable part of the Adenomatous Polyposis Coli protein and can be regulated by interactions with COOH-terminal domains, Cancer Research, 2005, 65 (12): 5195-5204. IF 9.234
Chenyun Guo, Zhuoyu Li, Jingming Yuan. Preparation of an immunoadsorbent coupled with a recombinant antigen to remove anti-acetylcholine receptor antibodies in abnormal serum. Journal of Immunological Method, 2005, 303: 142-147. IF 2.34
Chenyun Guo, Zhuoyu Li, Yawei Shi, Mingqun Xu, John G. Wise, Wolfgang E. Trommer, Jingming Yuan. Intein-mediated fusion expression, high efficient refolding and one-step purification of gelonin toxin. Protein Expression and Purification, 2004, 37: 361-367. IF 1.644
Zhuoyu Li, Yanjun Li, Chenyun Guo, Yewei Shi,Mingqun Xu, Wolfgang E. Trommer, Jingming Yuan. Soluble expression and affinity purification of functional domainof human acetylcholine receptor a-subunit by the modulation of maltose binding protein, Biotechnology Letters, 2004, 26: 1765-1769. IF 1.768
Hossann M, Kreilinger U, Buttner J, Vogel P D, Zhuoyu Li, Shi Y.-W, Yuan J, Wise J G, Trommer W E. Antigen-gelonin fusion protein for the treatment of Myasthenia gravis, Neuroimmunol. 2004, 154, 97. IF 2.32
Zhuoyu Li, Junhu Fan, Jingming Yuan. Single-column purification of recombinant human neurotrophin-3 (hNT3) by using the intein mediated self-cleaving system. Biotechonology Letters, 2002, 24 (20): 1723-1727(5).IF 1.768
剌晓琴，金小弟，张立超，李卓玉*。黄连素通过靶向GRP78增强结肠癌细胞对5-氟尿嘧啶的敏感性。山西大学学报（自然科学版），2019，已接收。统计源期刊
杨宇菲，张立超，剌晓琴，李卓玉*。胡麻粕多酚促进肠癌细胞凋亡的研究。食品科学，2018，已接收。一级学科主学报
张晓莉，单树花，李汉卿，史江颖，鲁洋，路晓庆，李卓玉*。重组谷糠源过氧化物酶的克隆、表达及逆转结肠癌化疗耐药活性。中国生物化学与分子生物学报，2018, 34(5):548-555. 一级学科主学报
李汉卿，刘丰铭，单树花，鲁洋，张晓莉，李卓玉*。酸枣自由态和结合态多酚对人主动脉平滑肌细胞表型转化的影响。食品科学，2018，已接收。一级学科主学报
刘小娜，晋小婷，苏瑞军，郭松佳，李汉卿，李卓玉*。低浓度TBBPA暴露促进子宫内膜癌细胞侵袭和迁移的毒性效应与机理。环境科学学报, 2018, 38(9):3746-3754. 一级学科主学报
张立超，李爱平，剌晓琴，李卓玉*。基于1H NMR代谢组学技术探究GRP78蛋白对巨噬细胞极化的干预效应。山西大学学报（自然科学版）, 2017, 40(1):160-168. 统计源期刊
李卓玉*，郭敏。地皮菜源天然产物的生物学活性及其应用。 山西大学学报（自然科学版）, 2017, 40(3):645-651. 统计源期刊
史江颖，单树花，李宗伟，郭松佳，史通麟，李卓玉*。谷糠结合态多酚对四种肿瘤细胞增殖的抑制作用。营养学报, 2015,37,178-184. 一级学科主学报
苏瑞军，晋小婷，安全，李瑞金，李卓玉*。太原市冬季大气PM2.5暴露对小鼠脏器及炎症因子的影响研究。环境与健康杂志, 2015, 32(8):677-679. 统计源期刊
郭松佳，郭向荣，单树花，武海丽，赵良启，李卓玉*。地皮菜水应激蛋白对结肠癌DLD1细胞黏附的影响。山西医科大学学报, 2015,5(46):416-420. 统计源期刊
刘建新，赵君宇，晋小婷，李卓玉*，宋莉。低浓度p, p’-滴滴涕对大肠癌SW620细胞增殖和凋亡的影响。中国药理学与毒理学杂志,2015,2(29):227-233. 统计源期刊
宋莉，尉文霞，常娇，李卓玉*。腺瘤息肉蛋白截短突变经PI3K/AKT 信号通路影响犬肾细胞MDCK 的细胞粘附。中国生物化学与分子生物学报, 2014, 30:355-361. 一级学科主学报
赵君宇，刘建新，晋小婷，贾慧，贾丹，李丹丹，李卓玉，宋莉。p, p’-DDT对大肠癌细胞DLD1细胞粘附的影响，安全与环境学报，2014，14(2):289-293. 统计源期刊
杨鹏，李宗伟，付荣，李汉卿，李卓玉*。丙酮酸激酶M1和M2的表达水平与结肠癌发展相关性研究。山西大学学报（自然科学版）, 2014, 37(3):447-453. 统计源期刊
晋小婷，贾宇鑫，李卓玉*，宋莉。三种抗癌中草药单一提剂及组合剂抑瘤率比较研究. 山西大学学报（自然科学版）, 2013,8: 480-483. 统计源期刊
郭松佳，单树花，晋小婷，李宗伟，宋莉，李卓玉*。地皮菜中一种新型水应激蛋白基因的克隆表达及其对结肠癌细胞的抑制作用。食品科学，2013, 35(13):151-155. 一级学科主学报
单树花，武海丽，李宗伟，袁琳洁，郭茂林，李卓玉*。小米米糠中抗癌细胞增殖活性蛋白的分离纯化，食品科学，2013, 34(9):296-300. 一级学科主学报
付荣，李宗伟，赵超，单树花，武海丽，李卓玉*。绿豆胰蛋白酶抑制剂精氨酸活性片段衍生物的克隆表达及生物活性研究。山西大学学报, 2013, 36(1):102-107. 统计源期刊
李文玲，祝文思，牛海波，朱峰，宋莉，李卓玉*。腺瘤息肉蛋白截短突变对MDCK细胞中细胞-基质和细胞-细胞间粘附的影响。复旦学报（医学版），2013, 40(2):133-139. 二级学科主学报
赵超，李宗伟，付荣，赵亚蕊，史通麟，李卓玉*。以葡萄糖调节蛋白78（GRP78）为靶向的胰蛋白酶抑制剂抗肠癌效应研究。复旦学报（医学版）, 2013, 40(2):148-152. 二级学科主学报
武海丽，单树花，袁琳洁，刘庆午，赵文彬，李卓玉*。玉米芯抗肿瘤活性研究。天然产物研究与开发, 2013, 25:229-233. 二级学科主学报
彭亚男，李承军，李斌，李卓玉*。敲减wingless/Wnt1基因表达对赤拟谷盗发育中的影响。中国生物化学与分子生物学报, 2012, 28(2):733-738. 一级学科主学报
赵亚蕊，李宗伟，赵邑，赵超，王兴华，李卓玉*。Wnt 信号通路调控肠癌细胞GRP78 表达与细胞膜转位。复旦学报（医学版）, 2012, 39(5):475-480. 二级学科主学报
李宗伟，付荣，赵亚蕊，赵超，李卓玉*。MG-132对缺氧、血清饥饿诱导的MSCs凋亡和旁分泌的影响。生理学报, 2011, 63(6):525–532. 一级学科主学报
李宗伟，赵亚蕊，赵超，付荣，李卓玉*。自分泌运动因子-溶血磷脂酸轴的生物学功能与调控。生理学报, 2011, 63(6):601–610. 一级学科主学报
伊凤双，李卓玉*。蛋白酶抑制剂对wnt信号通路的影响。国际肿瘤学杂志, 2010, 37(5):338-340. 统计源期刊
国家发明专利：
一种靶向抗肿瘤活性蛋白及其制备与纯化（2019），ZL201510718882.X，李卓玉，张立超，李宗伟，史通麟，杨鹏，李汉卿;
谷糠源过氧化物酶抗肿瘤活性片段及其制备方法和应用（2018），CN201810027037.1，单树花、张晓莉、李卓玉、李汉卿、武海丽、史江颖；
一种酸枣仁抗肿瘤结合态多酚及其制备方法和应用（2018），CN201810038716.9，单树花、解悦、李卓玉、李汉卿、郭松佳、鲁洋、张晓莉
一种地木耳抗肿瘤多糖及其制备方法和应用（2016），ZL201410459857.X，李卓玉、郭敏、郭松佳、单树花、李宗伟、卢德赵、李汉卿；
冬葵子活性蛋白的制备方法和应用（2016），ZL201410238318.3，李卓玉、陈美兰、宋莉、晋晓婷、李汉卿；
一种地皮菜水应激蛋白基因及其重组蛋白的制备和应用（2015），ZL201310291766.5，李卓玉、郭松佳、李宗伟、李汉卿、单树花；
一种谷糠抗肿瘤活性蛋白及其制备方法和应用（2014），ZL201210084160.X，李卓玉、单树花、武海丽、李宗伟、李砧；
一种胰蛋白酶抑制剂及其制备方法和应用（2013），ZL201210012186.3，李卓玉、李宗伟、赵超、李汉卿、史通麟；
一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用（2013），ZL201110313113.3，李卓玉、李宗伟、付荣、宋莉、赵亚蕊；
一种植物源农药及其生产方法和应用（2013），ZL201010259258.5，王兴华、李卓玉；
力生长因子多肽及其制备方法和用途（2012），ZL201010224435.6，宋莉、董俊丽、李卓玉、祝文思、刘晓辉。
Genebank 发表新基因（2013年发布地皮菜水应激蛋白基因）：
序列号为KF 003026